WebThe interaction between CBPs and valproic acid ... Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with … Web5.13 Interaction with Carbapenem Antibiotics 5.14 Somnolence in the Elderly 5.15 Monitoring: Drug Plasma Concentration ... In epileptic patients previously receiving valproic acid therapy, divalproex sodium delayed-release tablets should be initiated at the same daily dose and dosing schedule. After the patient is stabilized on divalproex ...
Valproic Acid and Carbapenem Antibiotics Interaction
WebMar 9, 2024 · Background: Valproic acid (VPA) is one of the most widely used broad-spectrum antiepileptic drugs, and carbapenems (CBPs) remain the drug of choice for severe infection caused by multidrug-resistant bacteria in critically ill patients. The interaction between VPA and CBPs can lead to a rapid depletion of serum VPA level. … WebJun 27, 2024 · Valproic acid (2-propylpentanoic acid; VPA) is a branched-chain carboxylic acid introduced as an anti-epileptic drug in 1978 in the United States. It is used to treat … john flowers basketball salary
Valproic Acid and Carbapenem Antibiotics Interaction
WebInteractions Enter a drug name and valproic acid All Interactions Sort By: Contraindicated (0) Serious - Use Alternative (19) adagrasib bremelanotide calcium/magnesium/potassium/sodium... WebApr 1, 2024 · The mechanisms for the interaction between VPA and carbapenems may include 1) decrease in VPA intestinal absorption and enterohepatic circulation; 2) increase in the synthesis and inhibition of VPA-glucuronide hydrolysis; 3) inhibition of VPA efflux from erythrocytes; and 4) increase in the urinary excretion of VPA-glucuronide. WebThirty-nine patients were treated simultaneously with valproate and meropenem. The pharmacokinetic interaction was observed in all 39 patients, with an average drop in valproate plasma concentrations of 66%, The decrease occurred within 24 hours, as shown in 19 patients who had daily plasma concentration monitoring, The clinical impact of the … john flowers basketball