Cisplatin hplc method

Author: mswk

August undefined, 2024

WebMar 24, 2016 · We describe an HPLC–UV method for determining cisplatin levels in liposomal and biological samples, which represents an attractive alternative to the … WebJun 13, 2005 · Cisplatin, cisplatinum or cis-diamminedichloroplatinum (II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes …

Review on Pharmacology of Cisplatin: Clinical Use, Toxicity and ...

WebAreas covered: In this review, we have discussed about cisplatin and its liposomal formulations, focusing on different preparation methods and analysis approaches such as atomic absorption, mass spectroscopy, UV, electrochemical methods, and emphasizing on HPLC as one of the accurate and specific methods for determination of cisplatin … grant spreadsheet template excel

Absorption spectra of cisplatin hydrochloride working standard...

Webderivitized cisplatin [21]. The objective of study was to develop and validate a direct and effective HPLC method for the simultaneous determination of etoposide and cisplatin which could be used in quality control analysis. The present work therefore is a direct method with good linearity and sensitivity for both drugs. O O O H HO H HO O O O O ... WebNov 1, 2005 · Abstract. A method for determination of cis -diaminedichloroplatinum (II) (cisplatin) in ultrafiltered plasma, cell, and tumour samples is described. Cisplatin … WebThe HPLC system (LC-20AD model, Shimadzu, Kyoto, Japan) consisted of two pumps (LC 20-AT model), an automatic injector (9SIL-20AD model), an oven (CTO-20AS model), a spectrophotometric detector (SPD-M20A model), and a computer equipped with the analysis software Shimadzu LC. chipmunk\u0027s hm

Effect of different shielding conditions on the stability of Cisplatin ...

P4394pis - Sigma-Aldrich

WebAug 15, 2007 · The HPLC method was developed for individual as well as simultaneous determination of two drugs namely carboplatin and paclitaxel in the presence of polymer … WebCisplatin, referred to by chemical name as cis-diamminedichloroplatinum (II), is anticancer, neutral and DNA destroying agent that is square planar platinum (II) complex and contains 2 ligands of chloride in a cis configuration orientation. 1 Cisplatin has been cited as being among the most used cytotoxic anticancer medication due to its ... grants program finder business.gov.auWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … grants programs for small business nonprofit

"WebSep 1, 2016 · An isocratic reversed-phase high-performance liquid chromatographic method with ultraviolet detection at 254 nm has been developed for the determination of doxorubicin in human plasma. Plasma... " - Cisplatin hplc method

Cisplatin hplc method

A Simple And Sensitive HPLC Method For Determination …

WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. WebNov 1, 2008 · Purpose: The purpose of this study was to develop and validate HPLC-UV method for the determination of the cisplatin, based …

Did you know?

WebThe platinum content (4.91%) of Polycisplatin was determined by modified HPLC–UV method detailed in the literature. 19 Briefly, a known amount of Polycisplatin was dissolved in 0.5 M HCl solution and stirred so as to cleave the AA-Pt bond and release the cisplatin. The cisplatin was then treated with 100 µL of (10%) DDTC in 0.1 N NaOH and ... WebMar 11, 2024 · Cisplatin (CDDP), a platinum-based drug, is the most potent anti-cancer agent and is widely used for cancer treatment [ 1 ]. In particular, it plays crucial roles in …

WebJun 4, 2000 · The cisplatin recovered in the swabbing solution can be analyzed by HPLC using direct injection or preconcentration, depending on the expected level of cisplatin in the sample. Initial methods were developed to quantitate at a cisplatin concentration of about 100 PPB or higher in solution extracted from surfaces. WebAug 23, 2012 · Establishing HPLC/ICP-MS quantification methods. For quantification of Cisplatin–DNA adducts, IDA was chosen. For the adduct d(GpG)-Pt(NH 3) 2, Garcia Sar et al. already published a suitable approach. 21 In order to monitor multiple adducts, we have chosen species-unspecific IDA (SU-IDA). With SU-IDA it is possible to study the …

WebThe method was successfully applied for routine analysis of Oxaliplatin tablet dosage form and bulk drug. Key Words:Oxaliplatin, RP-HPLC, UV detection, recovery, precise, 240nm INTRODUCTION Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. oxaliplatin is the platinum-containing complex similar to cisplatin. WebCisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because this agent …

WebA method of preparation and physical properties including the pK a of several species of cisplatin in water,2 the UV and visible spectra, HPLC methods, and mass spectra have been reported.1 Cisplatin is a platinum-containing, broad activity antineoplastic and alkylating agent effective against solid tumors of testes, ovaries, and bladder ...

http://www.ijsit.com/admin/ijsit_files/ijsit_1.1.5.pdf chipmunk\u0027s htWebCisplatin, cis-diamminedichlorido-platinum(II), is an important therapeutic tool in the struggle against different tumors, yet it is plagued with the emergence 掌桥科研一站式科研服务平台 chipmunk\u0027s hnhttp://www.ijsit.com/admin/ijsit_files/ijsit_1.1.5.pdf chipmunk\u0027s hwWebJun 12, 2000 · In water, the antineoplastic drug cisplatin, cis-[PtCl2(NH3)2] (1) hydrolyses slowly to the aqua complexes cis-[Pt(NH 3) 2 Cl(H 2 O)] + (2) and, to a small extent, cis-[Pt(NH 3) 2 (H 2 O) 2] 2+ (3), which are thought to play an important role in the metabolism of cisplatin.HPLC is a useful technique for monitoring 2 and 3, but only if the … grants printing dublinWebCisplatin is an antineoplastic drug used for the treatment of cancer patients with a variety of different malignancies. Application Cisplatin may be used as an analytical reference standard for the determination of the analyte in plasma, cancer cell, and tumor samples by high-performance liquid chromatographic assay. grants qsmo marketplaceWebJul 13, 2016 · The HPLC method was successfully applied to in vitro studies and enabled us to quantify CDDP not only in the NaCl medium but also in the cellular lysates using only 0.02 mL of a sample. Our results clearly demonstrate that the intracellular CDDP concentrations in EHD1-overexpressing cells were lower than those in control cells. grants publishingWebApr 24, 2024 · Doxorubicin hydrochloride. Several methods such as LC-MS, reverse phase HPLC and UV-Visible spectrometry have been reported and validated for quantitative analysis of doxorubicin hydrochloride in bulk and pharmaceutical dosage forms [12,13,14, 22, 23].All these methods require use of solvents, however due to unstable … chipmunk\u0027s hx