Ctcf properties
WebFeb 28, 2005 · CTCF is a nuclear protein ubiquitously expressed in many different proliferating and differentiated cell types [2], [3]. The presence of the CTCF protein in many cell types raises the possibility that post-translational modification could be a mechanism controlling transcriptional properties of the universally expressed CTCF protein. WebSep 16, 2024 · Other domains of CTCF do not show similar properties. Accordingly, endogenous CTCF forms small protein clusters and binds genomic regions with a high abundance of CTCF motifs but low densities of transcriptional activators, which is consistent with a spatial segregation model of CTCF insulation (Figure S5 A). Furthermore, the …
Ctcf properties
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WebNov 11, 2024 · Luan, J. et al. Distinct properties and functions of CTCF revealed by a rapidly inducible degron system. Cell Rep. 34 , 108783 (2024). Article CAS PubMed PubMed Central Google Scholar Web5.1 CTCF genome organizer and the cohesin complex. CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic contexts. CTCF was first isolated and cloned on the basis of its ability to bind to highly divergent 50–60 bp sequences within the promoter region of the chicken Myc gene ...
WebMay 6, 2013 · CTCF has it all. The transcription factor binds to tens of thousands of genomic sites, some tissue-specific, others ultra-conserved. It can act as a transcriptional activator, repressor and insulator, and it can pause transcription. CTCF binds at chromatin domain boundaries, at enhancers and gene pr … WebMar 21, 2024 · The intronic binding sites for cohesin and CTCF coincide with histone modifications that confer enhancer-like properties, and two of the cohesin/CTCF sites behaved as insulators in an in vivo assay. Data show that CCCTC binding factor (CTCF) binding was enriched at the Bax CTCF binding sites (CTSs) in breast cancer cells and …
WebEach set also includes a negative control antibody to ensure specificity of the ChIP reaction. The ChIPAb+ CTCF set includes the CTCF antibody, a negative control antibody (normal … WebFeb 28, 2005 · CTCF is a transcription factor involved in various aspects of gene regulation. We previously reported that CTCF function is modulated by protein kinase CK2. In this report we investigate further the role of CK2 in regulating the transcriptional properties of CTCF. We demonstrate that coexpression of …
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WebCTCF is a nuclear protein initially discovered for its role in enhancer-promoter insulation. It has been shown to play a role in genome architecture and in fact, its DNA binding sites are enriched at the borders of chromatin domains. Recently, we showed that depletion of CTCF impairs the DNA damage response to ionizing radiation. To investigate the relationship … fish to put in an aquariumWebAug 12, 2024 · This mathematical property of the CTCF grammar led us to hypothesise that divergent and convergent CTCF sites occur at different spatial regimes and that this underlies the emerging dimensions of TADs and their boundaries. We therefore analysed the distributions of CTCF cluster sizes along the human genome. This revealed that, at … fish toppings recipesTranscriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus … See more The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures like the nuclear lamina. It also defines the boundaries between active and … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with cohesin, which extrudes chromatin loops by … See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs … See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and … See more fish torchWebApr 14, 2024 · Finally, both TE-derived and native loops exhibit similar CTCF-binding properties (Fig. 4a–c) and patterns of activating histone marks (Supplementary Fig. 4). … fish to reduce cholesterolWebJan 14, 2024 · The 3D structures of chromosomes in vertebrate cells play a critical role in nearly all nuclear processes, including transcriptional control of gene expression, replication of DNA, repair of DNA damage, and splicing of messenger RNA (1–4).A key player in chromatin organization is the CCCTC-binding factor (CTCF), an 11-zinc finger (11ZF) … fish to put with goldfishWeb5.1 CTCF genome organizer and the cohesin complex. CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic … fish to put with betta fishWebCTCF is a highly conserved, multifunctional zinc finger protein involved in critical aspects of gene regulation including transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, and higher order chromatin organization. Such multifunctional properties of CTCF suggest an essential role in development. candy crush soda level 3766