WebAug 25, 2011 · DEP-mediated Cyp1b1 induction was inhibited by actinomycin D, cycloheximide, or by an AhR antagonist. In contrast, a sub-chronic in vivo treatment with … WebThe AhR is a cytosolic ligand-dependent transcription factor activated by both endogenous and exogenous chemicals. It can regulate expression of many target genes including some inflammatory...
Influence of TCDD on Zebrafish CYP1B1 Transcription …
WebDescription: Homo sapiens cytochrome P450 family 1 subfamily B member 1 (CYP1B1), mRNA. (from RefSeq NM_000104) RefSeq Summary (NM_000104): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and … WebAug 6, 2024 · The precise mechanisms through which TCDD induces toxicity are not fully understood; however, almost all of its effects are mediated through the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that is a member of the bHLH-PAS (basic-helix-loop-helix-Per-ARNT-Sim) superfamily. highway verge cutting
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Cytochrome P450 family 1 (CYP1) heme-thiolate monooxygenases participate in the bioactivation of a variety of potent hydrophobic … See more Czech Science Foundation (P503/11/1227 to J.V., 14-09979S to D.B.); Internal Grant Agency of the Ministry of Health of the Czech Republic (NT14599-3/2013 to J.K.); Czech Ministry of … See more The tumor- and cell-specific pattern of expression of CYP1B1, together with its ability to bioactivate a wide range of carcinogens, has … See more WebNov 22, 2024 · Pathological role of AhR/CYP1A1 in the pancreas: activation of AhR in the pancreatic islets upon exposure to ligands such as TCDD, leads to induction of CYP1A1, with subsequent generation of ROS and disruption of PKC and mitogen activated protein kinases (MAPK) signaling pathways, resulting in impaired insulin secretion and glucose … WebThe suppressive effects of TCDD occur early during CD4(+) T-cell. Activation of the aryl hydrocarbon receptor (AhR) by its prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mediates potent suppression of T-cell dependent immune responses. The suppressive effects of TCDD occur early during CD4(+) T-cell small to go coffee mugs with handle