H89 dihydrochloride kinase inhibitor

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August undefined, 2024

WebH-89 Dihydrochloride C20H22BrCl2N3O2S CID 5702541 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... WebJun 3, 2008 · Signaling through the cyclic adenosine monophosphate–dependent protein kinase [protein kinase A (PKA)] is an important and widely studied area of signal transduction research. This signaling pathway is commonly investigated through the use of the pharmacological PKA inhibitors H89 and KT 5720. Both of these compounds are …

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Webwith the protein kinase A (PKA) antagonist, H89, and the protein kinase C (PKC) antagonist, calphostin C, and fever was induced using lipopolysaccharide (LPS) in order to detect the expression of TRPV1 and phosphorylated (p-)TRPV1, the intracellular Ca 2+ concentration [(Ca) i] of hypothalami and rat body temperature. WebOct 8, 2016 · H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM and has weak inhibition on PKG, PKC, … eset urlフィルタ

H-89 dihydrochloride PKA Inhibitor MedChemExpress

WebBackground. H 89 2HCl is a potent PKA inhibitor. In a cell-free assay, the Ki of H 89 is 48 nM, 10-fold selective for PKA than PKG and 500-fold greater selectivity than PKC, MLCK, calmodulin kinase II and casein … WebH-89, Dihydrochloride - 2040089. 2040089. Reference overview. Pub Med ID. Characterization of activators and inhibitors of protein kinase C mu. Johannes, F J, et … WebH89 dihydrochloride, Kinase inhibitor (ab120341) Specific References (5) Description: Kinase inhibitor. NKH 477 (Colforsin daropate), an adenylyl cyclase activator (ab120240) Description: Water-soluble analogue of forskolin (ab120058), an adenylyl cyclase activator. 2-APB, Ca2+ release modulator (ab120124) eset urlフィルタリング

H-89, Dihydrochloride Cell Signaling Technology

WebTheir results showed that even the most selective inhibitors affected at least one other kinase. Interestingly, a recent study by Sheinerman et al. (67) reported that the different high affinity targets of a given kinase inhibitor have similar residues at the specific posi-tions important for the kinase-inhibitor association. http://yq.cnreagent.com/s/sv131850.html eset usb ブロックWebA cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (K i = 48 nM). View Price and Availability. Sigma-Aldrich. B1427. H-89 … eset url ブロック

"WebKinase inhibitor, commonly used as a protein kinase A inhibitor (IC50 = 135 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII (IC50 values are 120, 80 and … " - H89 dihydrochloride kinase inhibitor

H89 dihydrochloride kinase inhibitor

Web製品説明. H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase ( protein kinase A) with IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase, and others kinases. IC 50 & Target. IC50: 48 nM (protein kinase A) 体外実験. H-89 inhibits protein kinase A, in competitive fashion against ATP. WebY-27632 is a research tool with a wide variety of biological effects, mainly used in the field of stem cell research for maintenance and differentiation. Commonly used as 3D growth matrix component; also a component of brain organoid differentiation media. *Also available in simple stock solutions ( ab144494) - add 1 ml of water to get an exact ...

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WebIn the present study, using an in vivo experimental method, rat brain ventricles were injected with the protein kinase A (PKA) antagonist, H89, and the protein kinase C (PKC) antagonist, calphostin C, and fever was induced using lipopolysaccharide (LPS) in order to detect the expression of TRPV1 and phosphorylated (p‑)TRPV1, the intracellular ... WebH-89 dihydrochloride is an inhibitor of PKA and MSK, inhibits cyclic-AMP response element binding protein-mediated MAPK phosphatase-1 induction by lipopolysaccharide. …

WebMar 9, 2024 · However, the PKA inhibitor, H89 dihydrochloride, and the PI-3K inhibitor, wortmannin had no effect on the ANG II-mediated transcriptional activity of Npr1 (Fig. 4A,B). WebA cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (K i = 48 nM). Inhibits other kinases only at much higher concentrations: CaM …

WebBiological target: H-89 dihydrochloride is a potent and selective inhibitor of protein kinase A (PKA) with an IC50 of 48 nM. In vitro activity: Mouse embryonic fibroblast (MEF), human bronchial epithelial (hBE), human bone osteosarcoma epithelial (U20S), hepatocellular carcinoma (HepG2), human pancreatic carcinoma (MIA PaCa-2), and mouse myoblast … WebBiological target: H-89 dihydrochloride is a potent and selective inhibitor of protein kinase A (PKA) with an IC50 of 48 nM. In vitro activity: Mouse embryonic fibroblast (MEF), …

WebH-89 is a potent, cell permeable inhibitor of PKA that demonstrates an IC 50 value of 0.14 µM and a K i value of 48 nM in standard kinase assays. 1,2 While widely used to disrupt …

WebNov 15, 2024 · In this experiment, after injection of LPS, the expressions of TRPV1, p-TRPV1 and (Ca 2+) i in the PO/AH area increased and the temperature rose; and after a meantime injection of the PKA inhibitor H89 (1 or 1.5 µg/site) or the PKC inhibitor calphostin C (200 ng/site), the expressions of p-TRPV1 in the PO/AH area were … eset v10 アップデートWebSynonyms: Protein kinase inhibitor H-89 dihydrochloride, 5-Isoquinolinesulfonamide, H 89 2HCl. H 89 is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM). All products from TargetMol are for Research Use Only. ... Reber LL, et al. The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma. PLoS ... eset v10 バージョンアップWebAKT3+AKT2+cAMP Protein Kinase Catalytic subunit+ROCK2 (1) ... H89 dihydrochloride, Kinase inhibitor (ab120341) Specific References (6) Description: Kinase inhibitor. A-3 hydrochloride, PKA, PKG, Casein Kinase I and II inhibitor (ab143761) Description: Inhibits cAMP and cGMP dependent protein kinases. Also inhibits MLC kinase, casein kinase I ... eset urlブロック