WebThese categories are the following: (i) membrane trafficking (vesicular trafficking) including organelle-related; (ii) membrane contact sites; (iii) autophagy; (iv) cytoskeleton … Web19 jan. 2024 · We systematically examined fifteen hGAT-1 disease variants, all of which dramatically reduced or completely abolished GABA uptake activity. Many of these loss-of-function variants were absent from their regular site of action at the cell surface, due to protein misfolding and/or impaired trafficking machinery (as verified by confocal …
Prathyush Pothukuchi, PhD - Postdoctoral Fellow
WebOpen Access Membrane trafficking pathways are essential for the viability and growth of cells, and play a major role in the interaction of cells with their environment. In this At a … WebER-Golgi trafficking involves bulk flow and efficient recycling of H/KDEL-bearing proteins. Sorting in the Golgi stacks separates bulk flow to the plasma membrane from receptor … houter meaning
Membrane trafficking - Latest research and news Nature
Web1 jan. 2024 · Apolipoprotein CIII (ApoCIII) represents a key regulator of plasma lipid metabolism and a recognized risk factor for atherosclerosis and cardiovascular diseases. Beyond the regulation of lipoprotein trafficking, ApoCIII is also involved in endothelial dysfunction and monocyte recruitment related to atherothrombosis. WebProtein S-palmitoylation is a reversible post-translational lipidation in which palmitic acid (16:0) is added to protein cysteine residue by a covalent thioester bond. This modification plays an active role in membrane targeting of soluble proteins, protein–protein interaction, protein trafficking, and subcellular localization. Moreover, palmitoylation is related to … WebLaboratory for Membrane Trafficking, Center for Human Genetics (KULeuven) & VIB-Center for the Biology of Disease, Gasthuisberg O&N4, Herestraat 49, Leuven, B-3000 … houter mini opslag