WebApr 2, 2012 · We conclude that phosphorylation of T234 and S235 regulates OCT4 transcription primarily by altering its DNA binding capacity. Reprogramming experiments … WebPhosphorylation of Human Estrogen Receptor a by Protein Kinase A Regulates Dimerization DONGSHENG CHEN, PAUL E. PACE, ... (LBDs) and regulate transcription by binding to cis-acting enhancer elements in promoters of responsive genes as monomers or as homo- or heterodimers (12, 13, 55, 56, 83). Comparison of the amino acid sequences of
Regulation of the protein stability and transcriptional activity of ...
WebDec 11, 2015 · For instance, the level of OCT4, also known as POU5F1, is crucial for cell fate transitions and embryonic development.12,13If OCT4 protein is elevated more than 2-fold compared to normal conditions, stem cells loose their pluripotency and start differentiation into endoderm and mesoderm.14Moreover, a moderate increase of OCT4 is sufficient to … WebMay 8, 2012 · We conclude that phosphorylation of T234 and S235 regulates OCT4 transcription primarily by altering its DNA binding capacity. Reprogramming experiments … the pastry parlour aldgate
Histone demethylase KDM5 regulates cardiomyocyte maturation …
WebPhosphorylation of T234 and S235 on OCT4 Regulates DNA Binding. Phosphorylation sites on OCT4 were scattered throughout the protein (Fig. 1A); however, two sites (T234 and … WebPhosphorylation regulates human OCT4. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7162-8. doi: 10.1073/pnas.1203874109. Epub 2012 Apr 2. PubMed ID. 22474382 [ View in PubMed] Abstract. The transcription factor OCT4 is fundamental to maintaining pluripotency and self-renewal. To better understand protein-level regulation of OCT4, we … WebJan 29, 2014 · MG132, a proteasome inhibitor, blocked LY294002-induced Oct4 reduction, indicating that Oct4 protein level is regulated by PI3K/Akt signaling via proteasome-dependent mechanism. Furthermore, analysis of Oct4 protein sequence revealed that it contained a consensus Akt phosphorylation motif. the pastry place windsor