Web4 Apr 2024 · 3.3.1 Protein quality control . Spliced XBP1 plays a direct role in the UPR and mediates multiple downstream target genes, which deserves further review . ... inhibition of LPS-induced splicing of XBP-1 mRNA and production of IL-6 and TNF-α in macrophages : Salicylaldehyde analogs: Under experiment phase: HEK293, MM1.s, and U266 cells; … WebThe Role of BiP and the IRE1α-XBP1 Axis in Rhabdomyosarcoma Pathology Cancers (Basel) September 30, 2024 Background: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children, and...
XBP-1 Antibody Product Data Sheet Tested Species Reactivity …
Web19 May 2015 · Tunicamycin (Tm)-induced XBP-1 splicing, GRP78 and CHOP gene expression were inhibited by verrucarin A. Cells pre-treated with verrucarin A at concentrations of 0, 5, 10, 20, and 30 nM or not with each dose for 1 h were exposed to 5 μg∙mL −1 Tm for 6 h in FaO cells. The arrows represent the unspliced form (us) and … Web23 Aug 2024 · To investigate if IRE1α RNase activity was also affected by HSV-1 infection, we determined the spliced XBP1 mRNA level by real-time PCR by using a primer set that selectively amplifies the spliced variant of XBP1 cDNA , and the degree of XBP1 splicing using primers that circumvent the spliced segment, which allows for both the spliced and … tacky christmas light tour
Matthew Timberlake, PhD - Senior Scientist - Marin Biologic
WebThis reaction converts XBP-1 from an unspliced XBP-1u isoform to the spliced XBP-1s isoform, which is a potent transcriptional activator that induces expression of many UPR … WebSpliced XBP1 mRNA induced by activated IRE1 is translated to the protein, a potent transcription factor that induces BiP expression. XBP1 is also induced by activated ATF6. … Web22 Jul 2024 · X-box binding protein 1 (XBP1) mRNA processing plays a crucial role in the unfolded protein response (UPR), which is activated in response to endoplasmic reticulum … National Center for Biotechnology Information tacky christmas jumpers